- South East Dublin Departments of Anaesthesia

Publications - UCD

SVUH Department of Anaesthesia
UCD Department of Physiology / Conway Institute

Lisiting of research undertaken by SVUH Department of Anaesthesia in conjunction with UCD Department of Physiology, Professor Paul McLoughlin and the Conway Institute, UCD between 2003 - 2016.



SVUH Anaesthesia – UCD Physiology Academic Output 2003-2015

N. Murphy, K. Gaynor, S.C. Rowan, S.M. Walsh, A. Fabre, J. Boylan, M.P. Keane, P. McLoughlin.
Altered expression of bone morphogenetic protein accessory proteins in murine and human pulmonary fibrosis.
American Journal of Pathology 2016; in press

N. Murphy, S. Fröhlich, T. Kong, J.F. Boylan, N. Conlon.
Utility of near infrared light to determine tissue oxygenation during hepatobiliary surgery. Journal of Clinical Monitoring & Computing.
In press [2]

G. Imberger, C. Gluud, MD, J. Boylan, J. Wetterslev.
Systematic reviews of anesthesiological interventions reported as statistically significant: problems with power, precision, and type 1 error protection.
Anesthesia & Analgesia.
2015; 121: 1611-22.

A. Puttapa, K. Sheshadri, J. Boylan, N. Conlon.
Large increases in both response and state entropy to awake values antagonized with administration of incremental rocuronium. British Journal of Anaesthesia. 2015

S. Frohlich, J. F. Boylan and P. McLoughlin, St Vincent's University Hospital, Dublin 4
CREB transcription factor mediates pulmonary hypoxic responses; implications for a novel therapeutic strategy in acute respiratory distress syndrome
British Journal of Anaesthesia 113 (5): 891–4P (2014)
Presented at the Delaney Medal Competition 2014, COI

Li L, Howell K, Sands M, Banahan M, Fröhlich S, Rowan SC, Neary R, Ryan D, McLoughlin P.
The α and Δ isoforms of CREB1 are required to maintain normal pulmonary vascular resistance.

PLoS One. 2013; 8:e80637.

Fröhlich S, Boylan J, McLoughlin P.
Hypoxia-induced inflammation in the lung: a potential therapeutic target in acute lung injury?

Am J Respir Cell Mol Biol. 2013;48:271-9

Cahill E, Rowan SC, Sands M, Banahan M, Ryan D, Howell K, McLoughlin P.
The pathophysiological basis of chronic hypoxic pulmonary hypertension in the mouse: vasoconstrictor and structural mechanisms contribute equally.

Exp Physiol. 2012;97:796-806. 

Nichol AD, O'Cronin DF, Naughton F, Hopkins N, Boylan J, McLoughlin P.
Hypercapnic acidosis reduces oxidative reactions in endotoxin-induced lung injury.

Anesthesiology. 2010;113:116-25. 

Nichol AD, O'Cronin DF, Howell K, Naughton F, O'Brien S, Boylan J, O'Connor C, O'Toole D, Laffey JG, McLoughlin P.
Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis.
Crit Care Med. 2009;37:2953-61.

O'Croinin DF, Nichol AD, Hopkins N, Boylan J, O'Brien S, O'Connor C, Laffey JG, McLoughlin P.
Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury.

Crit Care Med. 2008;36:2128-35. 

Hopkins N, Gunning Y, O'Croinin DF, Laffey JG, McLoughlin P.
Anti-inflammatory effect of augmented nitric oxide production in chronic lung infection.
J Pathol. 2006;209:198-205.

O'Croinin DF, Hopkins NO, Moore MM, Boylan JF, McLoughlin P, Laffey JG.
Hypercapnic acidosis does not modulate the severity of bacterial pneumonia-induced lung injury.

Crit Care Med. 2005;33:2606-12.

Hyvelin JM, Howell K, Nichol A, Costello CM, Preston RJ, McLoughlin P.
Inhibition of Rho-kinase attenuates hypoxia-induced angiogenesis in the pulmonary circulation.
Circ Res. 2005;97:185-91.

Laffey JG, Honan D, Hopkins N, Hyvelin JM, Boylan JF, McLoughlin P.
Hypercapnic acidosis attenuates endotoxin-induced acute lung injury.

Am J Respir Crit Care Med. 2004;169:46-56. 

Loughrey JP, Laffey JG, Moore BJ, Lynch F, Boylan JF, McLoughlin P.
Interleukin-1 beta rapidly inhibits aortic endothelium-dependent relaxation by a DNA transcription-dependent mechanism.
Crit Care Med. 2003;31:910-5.



SVUH Anaesthesia - Peer-reviewed Academic Output by UCD-affiliated staff during UCD Physiology link, 2003-2014

Murphy N, Vijayan A, Fröhlich S, O’Farrell F, Barry M, Sheehan S, Boylan J,  Conlon  N.
Remote ischemic preconditioning does not affect the incidence of acute kidney injury after elective abdominal aortic aneurysm repair. J Cardiothorac Vasc Anesth. 2014, in press

Fröhlich S, Murphy N, Kong T, Ffrench-O'Carroll R, Conlon N, Ryan D, Boylan JF.
Alcoholic liver disease in the intensive care unit: Outcomes and predictors of prognosis.
J Crit Care. 2014, in press.

Fröhlich S, Ryan O, Murphy N, McCauley N, Crotty T, Ryan D.
Discrepancies between clinical and autopsy diagnosis in liver transplant recipients - a case series.

Acta Gastroenterol Belg. 2013;76:429-32.

Fröhlich S, Murphy N, Boylan JF.
ARDS: progress unlikely with non-biological definition.

Br J Anaesth. 2013;111:696-9.

Fröhlich S, Ryan O, Murphy N, McCauley N, Crotty T, Ryan D.
Are autopsy findings still relevant to the management of critically ill patients in the modern era?
Crit Care Med. 2014;42:336-43.

Fröhlich S, Murphy N, Ryan D, Boylan JF.
Acute respiratory distress syndrome: current concepts and future directions.
Anaesth Intensive Care. 2013;41:463-72.

Fröhlich S, Murphy N, Doolan A, Ryan O, Boylan J.
Acute respiratory distress syndrome: underrecognition by clinicians.

J Crit Care. 2013; 28:663-8.

Fröhlich S, Donnelly A, Solymos O, Conlon N.
Use of 2-hour creatinine clearance to guide cessation of continuous renal replacement therapy.
J Crit Care. 2012;27:744.e1-5.

Ryan O, Fröhlich S, Crotty TB, Ryan D.
Rhizopus microsporus infection in an immunocompetent host: a case of immunoparalysis?

Anaesth Intensive Care. 2012;40:367-8.

O'Croinin D, Ni Chonghaile M, Higgins B, Laffey JG.
Bench-to-bedside review: Permissive hypercapnia.

Crit Care. 2005;9:51-9. 

Laffey JG, O'Croinin D, McLoughlin P, Kavanagh BP.
Permissive hypercapnia--role in protective lung ventilatory strategies.

Intensive Care Med. 2004;30:347-56.

Laffey JG, Tobin E, Boylan JF, McShane AJ.
Assessment of a simple artificial neural network for predicting residual neuromuscular block.
Br J Anaesth. 2003;90:4852

Honan DM, Breen PJ, Boylan JF, McDonald NJ, Egan TD.
Decrease in bispectral index preceding intraoperative hemodynamic crisis: evidence of acute alteration of propofol pharmacokinetics.
Anesthesiology. 2002;97:1303-5.

Laffey JG, Boylan JF, Cheng DC.
The systemic inflammatory response to cardiac surgery: implications for the anesthesiologist.
Anesthesiology. 2002;97:215-52